Selective serotonin reuptake inhibitors (SSRIs and SNRIs) have lengthy been marketed because the magical resolution to despair and anxiousness, promising reduction in a handy little tablet. However behind the shiny pharmaceutical advertisements and physician endorsements lies a much more troubling actuality. These medicine don’t simply alter your mind chemistry — they’ll hijack your feelings, disrupt your life, and result in penalties far worse than the situations they declare to deal with.
The truth is, there’s a unclean secret of the SSRI antidepressants — they trigger psychotic violence which generally ends in suicide and generally in horrific murder (e.g., mass shootings). Remarkably, this aspect impact was found all through their scientific trials, lined up by the drug firms, after which lined up by the FDA after the company acquired a deluge of complaints1 (39,000 within the first 9 years2) as soon as the primary SSRI, Prozac, hit the market.
Initially, the media would report on the prescriptions (SSRIs) mass shooters took. Nevertheless, a gag order went out, it grew to become inconceivable to know what medicines shooters have been on, and the subject grew to become taboo to debate. Luckily, that not too long ago modified (e.g., after an article I wrote compiling the proof they trigger mass shootings went viral, Tucker Carlson did a 2022 section on it and distinguished conservatives step by step started talking overtly about SSRI mass shootings3).
In July 2022 @TuckerCarlson broke a serious taboo by discussing the hyperlink between antidepressants and mass shootings—an issue that didn’t exist till SSRIs entered the market.
Regardless of being written off as a “conspiracy idea” trade research constantly confirmed that SSRIs trigger… pic.twitter.com/aSaPBndNzQ— A Midwestern Physician (@MidwesternDoc) January 7, 2025
Notice: I not too long ago realized via a CDC official that the CDC has been silently monitoring what mass shooters are on and located the SSRI hyperlink continues however has not disclosed it because of political earthquakes this admission would trigger.
The Toxicology Bell Curve
In toxicology, you’ll sometimes see extreme and excessive reactions happen a lot much less steadily than reasonable reactions:

Due to this, when a really regarding and unmistakable adversarial response happens (e.g., the COVID-19 vaccines inflicting sudden deaths in younger wholesome athletes), that means you’re solely seeing the tip of the iceberg and much much less extreme accidents are additionally occurring far more steadily.
For instance, one estimate4 discovered that of these vaccinated for COVID, 18% have been injured, 0.93% have been disabled, and 0.05% to 0.1% died, whereas one other survey5 discovered 41% of these vaccinated have been injured, with 7% being severely injured.
Within the case of the SSRIs, the psychotic violence they’ll create, sadly, can also be simply the tip of a really massive iceberg, and there are various much less extreme methods they warp your thoughts, physique, and feelings.
The Hidden Aspect Results of SSRIs
Many datasets present the hurt SSRIs trigger vastly outweighs any advantages. For instance, in a survey of 1,829 sufferers6 on antidepressants in New Zealand:
62% reported sexual difficulties |
60% felt emotionally numb |
52% felt not like themselves |
39% cared much less about others |
47% had skilled agitation |
39% had skilled suicidal ideation |
In that survey, different much less frequent reported negative effects (so as of reducing frequency) included: insomnia, nightmares, “fuzzy”/”zombie,” jaw grinding, sweating, blurred imaginative and prescient, constipation, disturbed/stressed sleep, anxiousness, coronary heart palpitations, problem pondering, fatigue/exhaustion, unusual/vivid goals, stiff muscle groups/joints, “mind zaps,” mania, extreme yawning, panic assaults, reminiscence loss, decreased motivation, evening sweats, and decreased urge for food.
This listing matches what I’ve seen in lots of different datasets7 (though others like feeling agitated, shaky, or anxious, indigestion, abdomen aches, and diarrhea are additionally generally reported).
Notice: One other main concern with SSRIs (which is unlikely to be detected on a symptom-based survey) is that SSRIs steadily trigger bipolar dysfunction.
Psychotic Violence — A Suppressed Fact
When Prozac was first delivered to market within the mid-Eighties, the pharmaceutical trade had not but satisfied the world that everybody was depressed and wanted an antidepressant. So, as an alternative (on condition that SSRIs work in the same method to a stimulant like Cocaine8) Prozac was initially marketed as a “mood-lifter.”
Likewise, in 1985 when the FDA’s security reviewer scrutinized Eli Lily’s Prozac utility, they realized Lily had “failed” to report psychotic episodes of individuals on the drug and that Prozac’s adversarial results resembled that of a stimulant drug.
In flip, the warnings on the labels for SSRIs,9 comparable to anxiousness, agitation, panic assaults, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, and mania, match the results generally noticed with stimulant road medicine comparable to cocaine and methamphetamine.
Notice: A big survey of discovered 44% stopped a psych med due to negative effects, 1 / 4 of which have been because of SSRI agitation.10
In mild of this, and SSRI violence generally being blamed on a “pre-existing psychological sickness” I thus compiled quite a few research (together with ones trade tried to bury) exhibiting the medicine themselves trigger violence. For instance:
• A Cochrane assessment11 assessed 150 research the place wholesome volunteers got SSRIs and located roughly one-third of them intentionally omitted discussing SSRI negative effects, and about half of the research have been by no means made publicly accessible (presumably to cover their regarding information).
In the end, 14 of the 150 research have been eligible for meta-analysis (since sufficient info existed in them for the researchers to know what really occurred), and in these 14 research, SSRIs have been discovered to double the danger of suicide.
• In 2000, David Healy revealed a research12 he had carried out with 20 wholesome volunteers — all with no historical past of despair or different psychological sickness — and to his huge shock two (10%) of them grew to become suicidal once they acquired Zoloft. Considered one of them was on her manner out the door to kill herself in entrance of a prepare or a automotive when a cellphone name saved her.
Each volunteers remained disturbed a number of months later and significantly questioned the steadiness of their personalities.
• Eli Lilly confirmed in 197813 that cats who had been pleasant for years started to growl and hiss on Prozac and have become distinctly unfriendly. As soon as Prozac was stopped, the cats returned to their standard pleasant habits in per week or two.
Notice: The FDA hypothesized that SSRIs may cut back violence in some however trigger a rise in violence in others.14 Likewise a assessment of 84 animal research confirmed that lowered aggression upon remedy with SSRI was mostly noticed, however generally the animals as an alternative grew to become extra aggressive.15
Sexual Dysfunction
One of many negative effects that I really feel greatest illustrates the poor risk-reward ratio of SSRIs is sexual dysfunction — as not with the ability to have intercourse is kind of more likely to make somebody depressed (and in some circumstances suicidal16) — therefore typically utterly invalidating the justification for taking an SSRI to “really feel joyful once more.”
For instance, a Spanish research17,18 of 5 of 1,022 sufferers on essentially the most generally prescribed SSRIs discovered:
- The medicine triggered sexual disturbances in 59% of them and 40% thought-about that dysfunction unacceptable
- 57% skilled decreased libido
- 57% skilled delayed orgasm or ejaculation
- 46% skilled no orgasm or ejaculation
- 31% skilled erectile dysfunction or decreased vaginal lubrication
Notice: Comparable outcomes have been obtained in different research,19 and I’ve met many women and men who continued to expertise sexual dysfunction lengthy after they stopped the SSRI (as this dysfunction is usually everlasting).
What I discover essentially the most superb about SSRI sexual dysfunction is that whereas psychiatrists are inclined to downplay or ignore it, they concurrently market SSRIs to deal with untimely ejaculation — which is yet one more instance of the drug trade attempting to have its cake and eat it (particularly on condition that most of the SSRI producers additionally promote medicine for erectile dysfunction).
Notice: One purpose this aspect impact is underneath acknowledged is that embarrassed sufferers typically gained’t report it except they’re particularly requested about it (e.g., within the Spanish research, whereas 59% of SSRI customers reported sexual dysfunction, solely 20% did so with out prompting20 — one thing unlikely to be performed in a drug trial geared toward getting a drugs to market).
Emotional Blunting — Shedding the Essence of Life
As soon as the SSRIs hit the market, I instantly seen that SSRIs generally dramatically altered the persona of those that took them. For instance, they typically destroyed the drive folks needed to make one thing of their life — and in some circumstances, I sadly watched that derailment proceed for many years.
Likewise, I started to listen to tales of individuals describing how their expertise of life was deadened, typically in a way not too completely different from how the medicine “numb” your sexuality. A few of the frequent tales included:
• Not having emotional responses to issues you need to have responses to — For instance, I noticed quite a few circumstances of individuals being in unhealthy jobs or relationships, seeing a health care provider for assist with their despair, rapidly being placed on Prozac, after which losing a decade of their life as a result of Prozac (or one other SSRI) eliminated their drive to depart that poisonous state of affairs. Likewise, I heard many individuals state that Prozac took away the enjoyment they felt in life.
• Shedding the depth and richness of life — This remark for example, does a wonderful job of illustrating that:

Notice: In psychiatry, this emotional anesthesia (not discovering issues as fulfilling as one used to) is named “emotional blunting.” Relying on the research (e.g., these talked about above) between 40% to 60% of those that take SSRIs expertise this aspect impact, and it’s generally rationalized as a obligatory trade-off for eradicating the emotional ache related to despair.
One of many biggest issues with our society is the idea that the media has marketed to us that we should always by no means need to really feel damaging feelings. In actuality, they’re a important element of the human expertise and are steadily obligatory for our development and figuring out the proper course for our lives. Sadly, to market despair (and SSRIs) it was essential to pathologize regular aspects of life and switch them into everlasting sicknesses requiring indefinite remedy.
Start Defects — A Hidden Consequence
As soon as a drug will get accepted, pharmaceutical firms will all the time attempt to broaden their marketplace for it (e.g., this is the reason after adults stopped wanting the preliminary COVID-19 vaccine, they pivoted to pushing it on kids — though kids have an virtually 0% probability of dying from COVID-19).
With SSRIs, the trade has likewise labored to push them on susceptible teams (e.g., foster kids, “struggling” college students, prisoners or parolees, pregnant moms, and the aged), and every group has suffered important penalties from these practices — notably since many are usually not allowed to say no the medicine. This glorious skit by Peter Gøtzsche illustrates the absurdity of pushing them on pregnant girls:
As a result of the SSRI’s have been shielded from scrutiny, they’re steadily pushed on sufferers (generally towards their consent) when the medicine dangers vastly outweigh their advantages. This skit for instance highlights the unconscionable SSRI recommendation pregnant girls steadily obtain: pic.twitter.com/X5zKC1Jzhv
— A Midwestern Physician (@MidwesternDoc) January 7, 2025
Pushing SSRIs on pregnant girls is rationalized by the actual fact girls steadily get depressed throughout or after their pregnancies (which is usually because of extreme copper ranges — one thing fairly simple to deal with naturally). Sadly, there are a selection of explanation why SSRIs are usually not secure throughout being pregnant. These embrace:
• SSRIs improve the danger of untimely births,21 with the best danger (a doubling) occurring if an SSRI is taken throughout the third trimester.
• SSRIs considerably improve the danger of septal defects22 (which regularly require coronary heart surgical procedure to restore). One research of 500,000 infants in Denmark discovered moms taking a single SSRI whereas pregnant triggered the probability of a septal defect of their baby to go from 0.5% to 0.9% and taking two or extra elevated it to 2.1%. Moreover, whereas on common taking an SSRI doubled the danger of a start defect, the elevated danger ranged from 34% to 225%, relying on the SSRI.
• SSRIs considerably improve the danger of persistent pulmonary hypertension in a new child child. One research of 1,173 infants discovered SSRIs elevated the danger of it by 6.1 occasions,23 whereas one other discovered the danger elevated by 4.29 occasions,24 whereas one other discovered it elevated by 2.5 occasions.25
On condition that this situation impacts 1 to 2 out of 1,000 births and is usually deadly, this “small” danger provides up fairly rapidly (however nonetheless this was not sufficient for the FDA to rethink its advocacy of those medicine for pregnant girls26).
Notice: Different new child problems linked to SSRIs embrace irritability, tremor, hypertonia, and problem sleeping or breastfeeding.
Sadly, after start SSRIs proceed to have an effect on the event of a kid. For instance, the package deal insert for Prozac states that after solely 19 weeks of remedy, kids misplaced 1.1 cm (0.43 inches) and 1.1 kg in weight (2.43 lbs.) in comparison with kids handled with placebo.27
The Position of Advertising in SSRI Recognition
A lot in the identical manner, the pharmaceutical trade spends exorbitant quantities of cash dishonestly advertising and marketing medicine, it would steadily concoct elaborate methods to make a ineffective (or worse) drug seem like value promoting to all of America (in my view greatest encapsulated by the idiom “Placing Lipstick on a Pig”28).
Since “despair” is so subjective, it’s even simpler to recreation this analysis. In consequence, when the “profitable” research of antidepressants are rigorously examined, like many different prescription drugs (e.g., the COVID and HPV vaccines), the advantages are comparatively inconsequential whereas the far better dangers are hid with elaborate reclassifications.
Notice: Antidepressants do work for a metabolic subset of sufferers (whose metabolic dysfunction will also be handled naturally). Sadly, physicians are by no means educated to display screen for these sufferers, as that screening would get rid of the vast majority of potential SSRI prospects.
Luckily, there are a number of metrics you can not cowl up. Probably the most well-known ones is total mortality (how many individuals in complete on vs. off the drug died) since you possibly can’t reclassify loss of life. One other is what number of sufferers voluntarily selected to cease taking a drugs:
• A assessment of 29 revealed and 11 unpublished scientific trials containing 3,704 sufferers who acquired Paxil and a pair of,687 who acquired a placebo, discovered an equal proportion of sufferers in each teams left their research early (suggesting Paxil’s advantages didn’t outweigh its aspect impact), and that in comparison with placebo, 77% extra stopped the drug due to negative effects and 155% extra stopped as a result of they skilled suicidal tendencies.29
• A research of seven,525 sufferers, discovered that 56% of them selected to cease taking an SSRI inside 4 months of being prescribed it.30
• A world survey of three,516 folks from 14 affected person advocacy teams discovered that 44% had completely stopped taking a psychiatric drug because of its negative effects.31
• A survey of 500 sufferers discovered 81.5% have been uncertain if their antidepressants have been obligatory.32
Put in a different way, if most sufferers really feel worse on a drugs they’re taking to “really feel good” than they do with out it, which means the trials proclaiming the medicines made sufferers really feel higher have been fraudulent.
In flip, 1000’s of remarkably comparable tales may be discovered on-line.33 Sufferers expertise a spread of beforehand unimaginable negative effects that shake the very basis of their world, assume one thing should be incorrect with them (therefore going via a interval of disbelief), discover no help or understanding throughout the medical area — after which ultimately notice they’d been trusting their docs to have a specific amount of data they don’t even have.
“And you realize, that is heartbreaking. I went via this, and I felt that the world had fallen out from beneath me. There wasn’t any medical security web. So the sociological phenomenon exists, and has not but filtered into drugs. Drugs has its personal methods of gathering info, and in psychiatry, for some purpose, they preserve asking one another what the reality is as an alternative of asking their sufferers. The affected person voice will not be very properly acknowledged in psychiatry in any respect.”34
Notice: This SSRI expertise mirrors many different pharmaceutical accidents (e.g., I’ve heard virtually similar tales from numerous people injured by the COVID-19 vaccines).
Most significantly, many sufferers report that their prescribers don’t warn them about most of the SSRI negative effects. Briefly, many individuals I do know haven’t solely needlessly been severely impacted by these medicine but additionally gaslighted35 by the docs they sought care from.
Conclusion
Through the years, I’ve requested numerous holistic docs what they contemplate to be the 5 most harmful, broadly pharmaceuticals within the market, and with out exception, SSRIs all the time make that listing. On this article, I’ve tried as an example a few of the most frequent harms of those medicine, however sadly it solely touches on the floor.
For instance, due to how they’re dosed, SSRIs are extremely addictive, and as soon as they’re partially decreased, quite a lot of extreme signs can onset (e.g., dose modifications generally proceeds SSRI suicides and homicides,36 which is why you need to by no means abruptly cease taking them).
Tragically, docs are usually not educated to acknowledge these withdrawals (docs sometimes as an alternative interpret them as a pre-existing sickness not being counteracted by the SSRI and proceed to push the medicine), and only a few know how one can safely taper sufferers off SSRIs.
Luckily, with the MAHA motion, that is starting to vary. For instance, contemplate what RFK Jr. said37 when he shared this text:

As such, for the primary time in my life, I’m sincerely hopeful this almost 40 12 months tragedy finally will finish.38 As such, it’s now crucial every of us do all we are able to to reveal the Forgotten Sides of Drugs so we are able to create public strain to finish these pharmaceutical atrocities and produce again the unbelievable pure therapies that have been faraway from the market to guard these grotesque pharmaceutical monopolies.
Creator’s notice: That is an abridged model of an extended article which discusses the above factors in far more element and discusses how one can safely withdraw from SSRIs. That article and its further references may be learn right here. Moreover, a companion article in regards to the despair trade and efficient pure therapies for despair may be learn right here.
A Notice from Dr. Mercola In regards to the Creator
A Midwestern Physician (AMD) is a board-certified doctor from the Midwest and a longtime reader of Mercola.com. I admire AMD’s distinctive perception on a variety of subjects and am grateful to share it. I additionally respect AMD’s want to stay nameless since AMD continues to be on the entrance traces treating sufferers. To seek out extra of AMD’s work, remember to take a look at The Forgotten Aspect of Drugs on Substack.
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